Genomics

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Genomics is the study of whole genomes of organisms, and incorporates elements from genetics. Genomics uses a combination of recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyse the structure and function of genomes.

We are living in the time where big datasets are easily available and can be used for finding interesting research questions. Biological data in the form of genome sequencing and electronic health records can reveal novel traits which may help in improving life expectancy. Genome sequencing is becoming cheaper; therefore, it is now available even for developing countries and it is expected that prices will go down further. This would help clinicians to diagnose disease precisely that would open up to the area of precision medicine. Genome sequencing will also provide opportunity for the researchers to dig important biological information. There are several public databases such as ENCODE that provide TF binding (ChIP-seq), gene expression level (RNA-seq) and open chromatin region information (DHSs) for several cell types. There are also databases i.e., COSMIC and TCGA which contain cancer mutations. This Bioinformatics lab facility is being used to mine above public datasets and NGS (Next Generation Sequencing) data produced from local facilities for development of Predictors.

 

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